Maternal Signs and Symptoms

Liver

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HELLP syndrome

Brain

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Brain hemorrhage

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Kidneys

Proteinuria

Other symptoms

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Breakdown of red blood cells and complications with liver
and blood coagulation

Edema

Water retention
and swelling

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Kidney disease
and protein in the urine

Hypertension

Blood pressure that
exceeds 140/90 mmHg

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Severe headaches

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Changes in vision

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Upper abdominal pain

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Nausea or vomiting

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Decreased urine output

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Shortness of breath

Fetal Problems

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Prematurity
Low birthweight

Growth retardation

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Brain haemorrhage

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Immature lungs

Respiratory problems

 
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Clinical Challenge

Preeclampsia is the deadliest complication of pregnancy:

10 million women affected worldwide every year, leading to 76,000 maternal deaths 500,000 perinatal deaths

Severe morbidities during and after pregnancy for mother and her offspring

 
 
 
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Diagnostic Challenge

It is a complex syndrome, consisting of several diseases:

Disease pathways are not yet explored

No accurate test for the general early screening

No tests for early disease identification 

No disease-specific preventive treatments

Economic Burden

Costs of preeclampsia in the USA:

Total annual costs: $ 2.18 billion

Per person costs: 

$ 8,200 - Cost of preeclamptic delivery

$ 659,156 - Lifetime treatment cost of a woman with  cerebrovascular event during pregnancy

$ 38,250 - Annual treatment cost of an offspring  with neurological disabilities

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