Original Research Papers
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1. N.G. Than, B. Sümegi, G.N. Than, Z. Berente, H. Bohn:
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Maternal Signs and Symptoms
Liver
HELLP syndrome
Brain
Brain hemorrhage
Kidneys
Proteinuria
Other symptoms
Breakdown of red blood cells and complications with liver
and blood coagulation
Edema
Water retention
and swelling
Kidney disease
and protein in the urine
Hypertension
Blood pressure that
exceeds 140/90 mmHg
Severe headaches
Changes in vision
Upper abdominal pain
Nausea or vomiting
Decreased urine output
Shortness of breath
Fetal Problems
Prematurity
Low birthweight
Growth retardation
Brain haemorrhage
Immature lungs
Respiratory problems
Clinical Challenge
Preeclampsia is the deadliest complication of pregnancy:
10 million women affected worldwide every year, leading to 76,000 maternal deaths 500,000 perinatal deaths
Severe morbidities during and after pregnancy for mother and her offspring
Diagnostic Challenge
It is a complex syndrome, consisting of several diseases:
Disease pathways are not yet explored
No accurate test for the general early screening
No tests for early disease identification
No disease-specific preventive treatments
Economic Burden
Costs of preeclampsia in the USA:
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Total annual costs: $ 2.18 billion
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Per person costs:
$ 8,200 - Cost of preeclamptic delivery
$ 659,156 - Lifetime treatment cost of a woman with cerebrovascular event during pregnancy
$ 38,250 - Annual treatment cost of an offspring with neurological disabilities
